Several antibodies may be able to remove Alzheimer’s plaques from the brain, according to new research carried about in mice. According to the latest research, several antibodies may be able to destroy Alzheimer’s plaques. These antibodies were revealed in mice bodies.
People who have the Alzheimer’s disease but don’t feel any symptoms have the amyloid beta plaques that start to develop in their brains. It can start 20 years before the symptoms will appear. Such changes can cause memory and cognitive loses.
These plaques consist of the proteins. The researchers at Washington University School of Medicine made a new research and have found antibodies that can destroy these proteins.
They had some clinical trials before with using antibodies to kill the plaques, but they haven’t passed these trial phases. So most of the treatments had the unstable side effects.
The new approach can solve the problem of side effects and stop Alzheimer’s plaques until their heart-breaking symptoms will begin.
The hundreds of millions of dollars are spent every year to find the way to treat the Alzheimer’s disease. But all these methods were helpless against the disease once it begins.
According to the latest research the key genetics of the disease was found with the biological marker in the brain which is called the amyloid beta protein plaques. These plaques consist of protein pieces that grow from the fatty membranes of neuron cells.
Normally, if we will find the way to break off these fragments the natural enzymes can break them so that they will not get a chance to build a clump. There is the reason that this natural waste is not removed from people with Alzheimer’s.
Scientists think that these proteins stick together and block the electrical signals which appear in the synapses and try to communicate with one another in different parts of the brain.
Leading pharmaceutical and biotech companies with academic researchers have looked to these antibodies that target the plaques. If this method will be approved by most of them such pharmaceutical giants as Eli Lily will have to drop the most perspective drugs they had been developing to struggle with the disease.
These antibodies have specific identities that help them to fight particular invaders and pathogens that appear in the blood. The new antibody experimented that doesn’t match the amyloid beta proteins but a smaller part of protein contained in them. This antibody was called APOE.
APOE gene is the best genetic predictor of Alzheimer disease. This gene can mitigate the damage done by amyloid beta proteins by aiming treatment at the APOE protein.
But, scientists are looking for solutions to stop or even prevent the development of the plaques which will cause the stop of Alzheimer. So the researchers made an experiment. They wanted to see if APOE can be used to search and destroy plaques as well as to containment them.
They tested antibodies used as fits for human APOE. They tested them on mice, along with Alzheimer’s plaques. They used antibodies as fits for human APOE. They tried them on mice, along with Alzheimer’s plaques. When antibodies made plaques to their target proteins, they started to attract the immune cells to start attacking the small protein and all vicious protein which was inside. And one performance was really effective.
The performance of one of these antibodies was particularly impressive. Over six weeks, the mice who were treated with HAE-4 had the level of amyloid beta proteins decreased to half what they had before treatment.
The researchers had worried because APOE eliminates fats and cholesterol from the blood and attacking could damage this process. But it was developed that the APOE in the plaques differs from APOE in the blood.
These antibodies also didn’t cause the same effect of inflammation that other antibodies had while targeting the larger amyloid proteins. So scientist will find the way to treat the disease with less immune activation. So we will not see such unwelcome side effect as the researchers found in previous experiments with antibodies
If this method will work with humans as well as with mice, it will provide a more safe and effective therapy with those whose brains were infected with Alzheimer.
If the plaques will be removed early enough, it will stop the changes occurred in the brain that will result in confusion, forgetfulness, and cognitive decline.